![]() ![]() It was first publically recognized in the United States in 1975 in the towns of Lyme and Old Lyme Connecticut as a result of an investigation into 51 cases (39 children) with a similar form of arthritis, although the first case was describe five years earlier by a dermatologist in Wisconsin. Lyme disease (LD) is the most common tick-borne infection in North America. It was also noted that there are a large number of both commercial (n = 42) and in-house developed tests used by private laboratories which have not been evaluated in the primary literature. Direct detection methods, culture and PCR of tissue or blood samples were not as sensitive or timely compared to serological testing. burgdorferi infection from early to late LD. There is a dramatic increase in test sensitivity with progression of B. burgdorferi ELISA™ and the two tier approach have superior specificity compared to proposed replacements, and the CDC recommended western blot algorithm has equivalent or superior specificity over other proposed test algorithms. ![]() Recent studies examining the sensitivity and specificity of various test protocols noted that the Immunetics® C6 B. clinical diagnosis, 22 studies compared two or more tests with each other and 8 studies compared a two-tiered serological test protocol to another test. clinical diagnosis, 7 studies compared culture or PCR direct detection methods vs. clinical diagnosis, 9 studies examined single immunoblot vs. clinical diagnosis, 24 studies examined single assays vs. Thirteen studies examined a two-tier serological test protocol vs. Included in the review are 48 studies on diagnostic tests used in North America published since 1995. The objective of this systematic review is to summarize the North American evidence on the accuracy of diagnostic tests and test regimes at various stages of LD. There are many diagnostic tests for LD available in North America, all of which have some performance issues, and physicians are concerned about the appropriate use and interpretation of these tests. There has been an increasing incidence of Lyme disease (LD) in Canada and the United States corresponding to the expanding range of the Ixodes tick vector and Lyme disease agent ( Borrelia burgdorferi sensu stricto). ![]()
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